| ncRNA name | PF-04523655 |
| ncRNA Category | siRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | retinas |
| Methods | siRNA injection, fundus photography (FP), fundus fluorescein angiography (FFA) and OCT |
| Expression pattern | associated |
| Functional description | PF-04523655 is a siRNA that inhibits the expression of the hypoxia-inducible gene, RTP801. A single IVT injection of PF-0523655 ≤ 3000 μg seems safe and well tolerated in eyes with neovascular AMD. |
| PubMed ID | 22627477 |
| Year | 2012 |
| Title | Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients. |
| Drug-related ncRNA | NO |
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